You can overdose on spironolactone (Aldactone) if you take too much of it. The effects can be serious. For instance, you may feel confused or dizzy. Y The effects can be serious. For instance, you may feel confused or dizzy. Minoxidil vs. Spironolactone Finasteride vs. Spironolactone Rogaine vs. Spironolactone Propecia vs. Spironolactone Nizoral vs. Spironolactone Related Searches Overdose and Pain Spironolactone and Hair Loss Overdose and Depression Spironolactone and Acne Overdose and Addiction Spironolactone and Minoxidil Overdose and Death Spironolactone and Finasteride Overdose and Suicide Spironolactone and. Worldwide, approximately three million people suffer sudden cardiac death (ie, death from heart disease within 1 h) annually. Of these, approximately 0.5 million people are younger than 50 years of age. Spironolactone shouldn't be taken with potassium-supplementing drugs or diets because the excessive potassium intake may cause hyperkalemia, which can lead to abnormal heart rhythms (arrhythmias). Background: Trimethoprim–sulfamethoxazole increases the risk of hyperkalemia when used with spironolactone. We examined whether this drug combination is associated with an increased risk of sudden death, a consequence of severe hyperkalemia. Can Spironolactone cause Sudden Death? Complete analysis from patient reviews and trusted online health resources, including first-hand experiences. Complete analysis from patient reviews and trusted online health resources, including first-hand experiences. If you take too much spironolactone, overdose symptoms may include fainting, dry mouth, decreased urination, and increased thirst. The effects of an overdose will vary depending on how much of the medication is taken and whether it is taken with alcohol or other drugs. Spironolactone, sold under the brand name Aldactone among others, is a medication that is primarily used to treat fluid build-up due to heart failure, liver scarring, or kidney disease. It is also used in the treatment of high blood pressure, low blood potassium that does not improve with supplementation, early puberty in boys, acne and. Spironolactone is a medication used for various conditions, including high blood pressure (hypertension) and water retention (edema). Spironolactone overdose effects will vary depending on a number of factors, including how much spironolactone is taken and whether it is taken with any other medicines, alcohol, and/or drugs. Summary. Death is found among people who take Spironolactone, especially for people who are male, 60+ old , have been taking the drug for 1 month, also take medication Lasix, and have Primary pulmonary hypertension.